The crash occurred at the southbound ramp for Exit 16A- Queen Street in York Township at approximately 2:44 p.m., according to the coroner's office.
Emergency crews arrived at the scene at approximately 3:02 p.m., according to the release.
One victim died at the scene and was pronounced dead at 3:50 p.m. by Deputy Coroner Jacob Clevenger according to the coroner's office.
The other two victims died at WellSpan York Hospital-- one was pronounced dead at 3:26 p.m. and the other at 3:32 p.m.-- by Deputy Coroner Karen Frank, according to the release.
The identities of the victims and details about the crash will be released later in the week, according to the release.
There were other victims involved in the crash but their statuses and conditions have not been released.
Follow Daily Voice for updates.
Click here to follow Daily Voice Hampden-Silver Spring and receive free news updates.